In Vitro Biological Activity of Three Marine Sponges From Theonella and Haliclona Genera Collected From Bidong Island, Terengganu, Malaysia

Marine sponges are primitive sessile animals that rich sources of biologically active compounds. This paper aimed to assess the in-vitro biological activity marine from Theonella and Haliclona genera collected Bidong Island, Terengganu, Malaysia. Biological activities such as antibacterial (discs diffusion assay), antioxidant (DPPH free-radical scavenging cytotoxicity (against cancerous HeLa, MCF-7, HepG-2 cell lines normal line Vero) were evaluated using MTT assay. The bioassays done on methanol extracts at different concentrations. Results indicate T. swinhoei, cf cupola showed low capabilities ranging 0 50 mg/mL exhibited medium with IC50 value 23.25 ± 1.57 18.52 0.86 mg/mL, respectively. Cytotoxicity both species swinhoei possesses toxic inhibit proliferation all cancer used demonstrated no significant toxicity for in this study. fascigera against Gram-positive bacteria Gram-negative used. an 1.80 0.08 outcomes assay cells below 30 µg/mL. study promising bioactive compounds can be excellent candidate drug discovery prospecting novel antibiotics anticancer. Despite showing activity, further studied other assays explore whilst sponge H. antibacterial, antioxidant, its chemical compositions future research.